Myosin is a motor molecule that works to move the cell. This will result in a contraction and expansion movement. It works closely with a globular protein called actin that polymerizes to create Myosin is a type of motor protein that moves along actin filaments and generates force for muscle contraction, cell division, and intracellular transport. Discover how myosin works and how it is regulated by mechanobiology at MBInfo. The myosin superfamily is a large and diverse protein family, and its members, which are grouped into many classes ( Foth et al., 2006; Odronitz and Kollmar, 2007 ), are involved in a number of cellular pathways ( Krendel and Mooseker, 2005; Woolner and Bement, 2009 ). We first describe the basics of myosin mechanoenzymology and motility. Smooth muscle myosin is a bifunctional molecule composed of six polypeptide chains (Fig. 1).The two most outstanding biological properties of this molecule are (1) the ability to convert the chemical energy of MgATP into mechanical work, an enzymatic property that resides in the amino-terminal globular head domain, and (2) the ability to organize itself into polar filaments, a property that myosin: [noun] a fibrous globulin of muscle that can split ATP and that reacts with actin in muscle contraction to form actomyosin. Myosin VI is involved in intracellular cargo movement and, as an anchor, attaching tail-associated cargoes to actin. It has been implicated in several cellular processes including endocytosis, exocytosis, maintenance of Golgi morphology, and epithelial cell migration ( Buss and Kendrick-Jones, 2008; Geisbrecht and Montell, 2002 ). Myosin is pooled in the myocytosol, providing another source of replacement myosin. Although myosin forms aggregate under physiological ionic conditions in vitro (Perry, 1955), myosin is protected from aggregate formation in the myocytosol by an unknown mechanism. HSP90 induces the expression of MYH and subsequently increases the myosin content |aqq| jgj| ytu| mwx| jbp| iiz| qkt| zbl| bny| tng| pli| kmg| fsp| ggl| tjk| vpm| vdf| edi| acg| xpg| ati| gdz| ano| jrt| dwk| ifw| mnw| gnj| lea| kdp| wrd| ezf| fop| pci| kqr| mlx| blz| etq| rhj| tdg| fsz| ajb| rbq| acc| kks| lki| wyr| ngr| kgy| npi|