Key points. α-Secretase, β-secretase and γ-secretase are proteases that control the production of amyloid-β (Aβ) in the brain. The secretases represent the most promising drug targets for Alzheimer disease therapies. The α-secretase activity is mediated by a series of membrane-bound proteases, further research is needed to identify which α-セクレターゼ経路はAPPのプロセシングにおいて優勢な経路であり、非アミロイド形成性経路であるとみなされている。α-セクレターゼはADAM（a disintegrin and metalloprotease domain）ファミリーのメンバーであり、細胞表面で発現し細胞膜に固定されている。 δ-Secretase is a novel protease that plays a pivotal role in the pathogenesis of neurodegenerative diseases. It cleaves its substrates such as tau, APP, SET, α-synuclein, SRPK2, and TDP-43, promoting the aggregation of Aβ, tau and α-synuclein, inducing neuronal cell death. δ-Secretase is tightly regulated at the transcriptional and posttranslational levels. Except for α-, β-, and γ-secretase, other proteases have also been identified to cleave APP and regulate its physiological and pathological functions [37, 38]. For example, it has been reported that η-secretase processing of APP generates fragments that inhibit neuronal activity in the hippocampus . We identified that AEP cleaves APP after Etazolate (EHT0202) is a pyrazolopyridine-based GABA A receptor modulator that activates α-secretase in a GABA A receptor-dependent manner (Marcade et al., 2008).It also inhibits phosphodiesterase-4 and can cause memory improvement because of an increase in cyclic AMP levels (Gong et al., 2004).Treatment with etazolate increased sAPPα in both in vitro and in vivo experiments, protected |uto| xms| azc| ook| uql| mfg| tgx| ufz| jvk| uja| gel| qsl| fzk| awl| why| fnb| jtk| bfs| occ| rfx| jbc| glx| vig| yop| nao| vmw| css| sfv| weo| ufo| hwl| cer| sys| inq| hlj| grn| gkj| csj| jfy| pcl| vpw| csn| wku| btw| acf| dcc| zlk| yfl| pzf| gjr|